Anticoagulants
- Active ingredient (INN)
- tranexamic acid
- Composition (active ingredients)
- tranexamic acid - 50 mg
- Фармакотерапевтическая группа
- hemostatic agent - fibrinolysis inhibitor
- Pharmacotherapeutic group
- solution for intravenous administration 50 mg/ml 5 ml №10
- Сonditions of supply
- on prescription
Indications
- menorrhagia and metrorrhagia;
- gastrointestinal bleeding;
- bleeding after surgery on the prostate and bladder;
- bleeding during surgical interventions in the nasal cavity, mouth and pharynx (adenoidectomy, tonsillectomy, tooth extraction);
- bleeding with thoracic, abdominal and other major surgical interventions (including cardiac surgery);
- obstetric and gynecological bleeding (including bleeding during gynecological surgery);
- bleeding caused by the use of fibrinolytic drugs.
Dosage regimen
- Adult patients.
-
- Treatment of menorrhagia and metrorrhagia, gastrointestinal bleeding
-
500 mg 2-3 times a day from the moment of bleeding until it stops
- Treatment of bleeding after surgery on the prostate and urinary tract
-
1000 mg 3 times a day from the moment of bleeding until it stops
- Prevention and treatment of bleeding during surgical interventions in the nasal cavity, mouth and pharynx
-
10-15 mg/ml body weight every 6-8 hours until the bleeding stops
- Prevention and treatment of bleeding with thoracic, abdominal and other extensive surgical interventions
-
15 mg/kg body weight every 6-8 hours until bleeding stops
- Prevention and treatment of bleeding during cardiac surgery
-
loading dose of 15 mg/kg after induction of anesthesia before surgery, then intravenous infusion at a rate of 4.5 mg/kg/hour throughout the operation; 0.6 mg/kg tranexamic acid is recommended for use in a heart-lung machine
- Treatment of obstetric and gynecological bleeding (including bleeding during gynecological surgery)
-
15 mg/kg body weight every 6-8 hours from the moment of bleeding until it stops
- Treatment of bleeding caused by the use of fibrinolytic drugs
-
10 mg/kg body weight every 6-8 hours from the moment of bleeding until it stops
- Children over 1 year old
-
experience with tranexamic acid in children is limited. The recommended dose of the drug in the treatment of bleeding due to local and generalized fibrinolysis is 20 mg/kg/day
- Patients with impaired renal function
-
in patients with mild to moderate impaired renal excretory function, dose and rate of administration of tranexamic acid should be adjusted
- Impaired liver function
-
in patients with impaired liver function, dose adjustment is not required
- Elderly patients
-
in elderly patients in the absence of renal failure, dose adjustment is not required
