Antispasmodics
- Active ingredient (INN)
- magnesium sulfate
- Composition (active ingredients)
- magnesium sulfate heptahydrate - 250,0 mg
- Фармакотерапевтическая группа
- vasodilator
- Pharmacotherapeutic group
- solution for intravenous administration 250 mg 10 ml №10
- Сonditions of supply
- on prescription
Indications
Intravenous (slow jet or drip). The patient should be in the supine position. Doses are specified taking into account the therapeutic effect and the concentration of magnesium ions in the blood serum- arterial hypertension (including hypertensive crisis with symptoms of cerebral edema)
- polymorphic ventricular tachycardia (pirouette type)
- eclampsia (to suppress seizures) and preeclampsia (to prevent seizures in severe preeclampsia)
- tetany uterus
- poisoning with salts of heavy metals (mercury, arsenic, tetraethyl lead)
- hypomagnesemia (including an increased need for magnesium and acute hypomagnesemia - tetany)
Dosage regimen
The drug should be taken in the minimum effective dose, for the shortest possible period of time.
Inside. The tablets are swallowed whole with a sufficient amount of liquid.
- Hypertensive crisis
-
intravenously (slowly over about 5 minutes) 5-20 ml magnesium sulfate solution 250 mg/ml
- Polymorphic ventricular tachycardia
-
intravenously 1-2 g (4-8 ml of the drug) for about 5 minutes, repeated administration is possible
- Preeclampsia and eclampsia
-
the dose is set individually, depending on the clinical situation. Saturation dose - 2-4 g (8-16 ml of the drug) after 5-20 minutes (infusion). Maintenance dose - 1-2 g (4-8 ml of the drug) per hour
- Tetany of the uterus
-
saturation dose - 4 g (16 ml of the drug) after 20 minutes (infusion). Maintenance dose - first 1-2 g (4-8 ml of the drug) per hour, later - 1 g (4 ml of the drug) per hour (can be administered drip for 24-72 hours)
- Hypomagnesemia
-
daily dose - 0,2-0,8 mg/kg intravenously slowly
- in newborns
-
mild: a solution of magnesium sulfate is used parenterally, if the oral route of administration of magnesium preparations is impossible or impractical (due to nausea, vomiting, impaired resorption in the stomach, etc.). The daily dose is 1-2 g (4-8 ml of the drug). This dose is administered once or in 2-3 doses
- in adults
-
severe: initial dose - 5 g (20 ml of the drug) intravenously slowly in 1 liter of infusion solution (0.9% sodium chloride solution or 5% dextrose (glucose) solution). The dose is selected depending on the concentration of magnesium ions in the blood serum
Prevention of hypomagnesemia in patients receiving only parenteral nutrition.
If there is no magnesium in the nutrient solutions, it is added additionally. The daily dose is 1,5-4 g. Usually, 1 g of magnesium sulfate is added to 1 liter of parenteral nutrition solution. The maximum daily intake of magnesium sulfate for adults is 40 g.
The doses of magnesium sulfate indicated above are given in grams, they correspond to the amount of solution 250 mg / ml: 1 g - 4 ml; 2 g - 8 ml; 3 g - 12 ml; 4 g - 16 ml; 5 g - 20 ml; 10 g - 40 ml; 15 g - 60 ml; 20 g - 80 ml; 30 g - 120 ml; 40 g - 160 ml.
A solution of magnesium sulfate is diluted with injection solutions: 0.9% sodium chloride or 5% dextrose (glucose).
With prolonged use, it is recommended to monitor blood pressure, heart activity, tendon reflexes, kidney activity, and respiratory rate.
If necessary, the simultaneous administration of calcium and magnesium salts, drugs should be injected into different veins.
