Cardio
- Active ingredient (INN)
- atorvastatin
- Composition (active ingredients)
- atorvastatin calcium trihydrate 10,85 mg, 21,70 mg, 43,40 mg (in terms of atorvastatin - 10,0 mg, 20,0 mg, 40,0 mg)
- Фармакотерапевтическая группа
- lipid-lowering agent - HMG CoA reductase inhibitor
- Pharmacotherapeutic group
- film-coated tablets 10, 20 and 30 mg №30
- Сonditions of supply
- on prescription
Indications
- as an adjunct to a diet to lower high total cholesterol, LDL-C, apo-B, and triglycerides in adults, adolescents, and children 10 years of age or older with primary hypercholesterolemia, including familial hypercholesterolemia (heterozygous variant) or combined (mixed) hyperlipidemia ( Fredrickson type IIa and IIb, respectively) when response to diet and other non-drug treatments is inadequate
- to lower high total cholesterol, LDL-C in adults with homozygous familial hypercholesterolemia, as an adjunct to other lipid-lowering therapies (eg, LDL apheresis) or if such treatments are not available
- prevention of cardiovascular events in adult patients with a high risk of developing primary cardiovascular events, as an adjunct to the correction of other risk factors
- secondary prevention of cardiovascular complications in patients with coronary artery disease in order to reduce mortality, myocardial infarction, strokes, repeated hospitalizations for angina pectoris and the need for revascularization
Dosage regimen
- Primary hypercholesterolemia and combined (mixed) hyperlipidemia
-
for most patients, the recommended dose of the drug is 10 mg 1 time per day; the therapeutic effect appears within 2 weeks and usually reaches a maximum after 4 weeks. With long-term treatment, the effect persists
- Homozygous familial hypercholesterolemia
-
in most cases, 80 mg is prescribed once a day (decrease in the concentration of LDL-C by 18-45%)
- Heterozygous familial hypercholesterolemia
-
the initial dose is 10 mg per day. The dose should be selected individually and the relevance of the dose should be assessed every 4 weeks with a possible increase to 40 mg per day. Then either the dose can be increased to a maximum of 80 mg per day, or it is possible to combine bile acid sequestrants with atorvastatin at a dose of 40 mg per day
- Prevention of cardiovascular diseases
-
in primary prevention studies, the dose of atorvastatin was 10 mg per day. It may be necessary to increase the dose in order to achieve the values of cholesterol-LDL corresponding to current recommendations
- Use in children from 10 to 18 years old with heterozygous familial hypercholesterolemia
-
the recommended starting dose is 10 mg once a day. The dose can be increased to 80 mg per day depending on the clinical effect and tolerability. The dose of the drug must be titrated depending on the goal of lipid-lowering therapy. Dose adjustments should be made at intervals of 1 every 4 weeks or more