Additionally
- Active ingredient (INN)
- iohexol
- Composition (active ingredients)
- iohexol - 518 mg, 647 mg, 755 mg (equivalent to iodine - 250 mg; 300 mg; 350 mg)
- Фармакотерапевтическая группа
- X-ray contrast agent
- Pharmacotherapeutic group
- solution for injection 240 mg, 300 mg, 350 mg iodine/ml; 20, 50 and 100 ml
- Сonditions of supply
- on prescription
Indications
Yogexol is for diagnostic use only.Radiopaque contrast agent for use in children and adults, designed to perform:
- cardioangiography, arteriography, urography, phlebography and radiopaque enhancement with computed tomography (CT);
- lumbar, thoracic and cervical myelography;
- CT cisternography after subarachnoid administration;
- arthrography, endoscopic retrograde pancreatography (ERPG), endoscopic retrograde cholangiopancreatography (ERCP), hysterosalpingography, herniography, sialography, and studies of the gastrointestinal tract.
Dosage regimen
General information:
The drug is intended for intravascular (intra-arterial, intravenous), intrathecal, intracavitary, oral and rectal administration. Like all drugs for parenteral administration, Yogeksol must be visually inspected before use for insoluble particles, discoloration and damage to the integrity of the package.
Yogeksol should be drawn into a syringe just before use. Unused residues of the drug are not allowed for further use.
Yogeksol should not be mixed with other medicines (you must use a separate syringe and needle).
When injecting the drug, the patient should be in a horizontal position. Within 30 minutes after the end of the procedure, medical supervision of the patient is carried out, since most of the adverse reactions occur during this period.
Intrathecal introduction:
After performing myelography, the patient should be at rest for at least 1 hour, lying with the head of the bed raised by 20 °. If you suspect a low threshold for the development of seizures, it is necessary to observe the subject for 6 hours. Patients on an outpatient basis should avoid bending over. Outpatients should not be left unattended for the first 24 hours after administration of a radiopaque contrast agent.
The dosage of the drug depends on the type of study, the age and body weight of the patient, as well as the state of hemodynamics, general health, as well as the methodology and technique used for performing the study. Usually, the same iodine concentrations and volumes of drug administration are used as with other modern iodine-containing X-ray contrast media.
- Intravenous (IV) administration:
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- Urography. Adults
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300 mg iodine/ml or 350 mg iodine/ml (40-80 ml). In some cases, it is possible to administer more than 80 ml
- Urography. Children weighing <7 kg
-
240 mg iodine/ml (4 ml/kg) or 300 mg iodine/ml (3 ml/kg)
- Urography. Children weighing > 7 kg
-
240 mg iodine/ml (3 ml/kg) or 300 mg iodine/ml (2 ml/kg, no more than 40 ml)
- Phlebography (lower limbs)
-
240 mg iodine/ml or 300 mg iodine/ml (20-100 ml/per limb)
- Digital subtraction angiography
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300 mg iodine/ml or 350 mg iodine/ml (20-60 ml per injection)
- CT scan. Adults
-
240 mg iodine/ml (100-250 ml) or 300 mg iodine/ml (100-200 ml) or 350 mg iodine/ml (100-150 ml). The total amount of iodine is usually 30-60 g
- CT scan. Children
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240 mg iodine/ml (2-3 ml/kg body weight - up to 40 ml) or 300 mg iodine/ml (1-3 ml/kg body weight - up to 40 ml). In rare cases, you can use up to 100 ml per child, but not more
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- Intra-arterial (i/a) administration:
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- Arteriography. Aortic arch
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300 mg iodine/ml (30-40 ml per injection). The injection volume depends on the injection site
- Arteriography. Selective cerebral angiography
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300 mg iodine/ml (5-10 ml per injection). The injection volume depends on the injection site
- Arteriography. Aortography
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350 mg iodine/ml (40-60 ml per injection). The injection volume depends on the injection site
- Arteriography. Femoral arteriography
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300 mg iodine/ml or 350 mg iodine/ml (30-50 ml per injection). The injection volume depends on the injection site
- Arteriography. Others
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300 mg iodine/ml (the volume depends on the type of study)
- Cardioangiography. Adults. Left ventricle and aortic root
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350 mg iodine/ml (30-60 ml per injection)
- Cardioangiography. Adults. Selective coronary angiography
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350 mg iodine/ml (4-8 ml per injection)
- Cardioangiography. Children
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300 mg iodine/ml or 350 mg iodine/ml (volume depending on age, weight and pathology; max. 8 ml/kg)
- Digital subtraction angiography
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240 mg iodine/ml or 300 mg iodine/ml (1-15 ml per injection). Large volumes (up to 30 ml) can be used depending on the injection site
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- Intrathecal administration:
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- Lumbar and thoracic myelography (lumbar injection)
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240 mg iodine/ml (8-12 ml). To minimize possible adverse reactions, the total dosage should not exceed 3 g
- Cervical myelography (lumbar injection)
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240 mg iodine/ml (10-12 ml) or 300 mg iodine/ml (7-10 ml). To minimize possible adverse reactions, the total dosage should not exceed 3 g
- Cervical myelography (lateral cervical injection)
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240 mg iodine/ml (6-10 ml) or 300 mg iodine/ml (6-8 ml). To minimize possible adverse reactions, the total dosage should not exceed 3 g
- CT cisternography (lumbar injection)
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240 mg iodine/ml (4-12 ml). To minimize possible adverse reactions, the total dosage should not exceed 3 g
- Myelography in children < 2 years of age
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2-6 ml. Dilute with water to a concentration of about 180 mg iodine/ml. To minimize possible side reactions, the total dosage should not exceed 3 g
- Myelography in children 2-6 years old
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4-8 ml. Dilute with water to a concentration of about 180 mg iodine/ml. To minimize possible adverse reactions, the total dosage should not exceed 3 g
- Myelography in children > 6 years of age
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6-12 ml. Dilute with water to a concentration of about 180 mg iodine/ml. To minimize possible adverse reactions, the total dosage should not exceed 3 g
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- Introduction to body cavities:
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- Arthrography
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240 mg iodine/ml (5-20 ml) or 300 mg iodine/ml (5-15 ml) or 350 mg iodine/ml (5-10 ml)
- ERCP/ERPG
-
240 mg iodine/ml (20-50 ml)
- Herniography
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240 mg iodine/ml (50 ml). The dose depends on the size of the hernia
- Hysterosalpingography
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240 mg iodine/ml (15-50 ml) or 300 mg iodine/ml (15-25 ml)
- Sialography
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240 mg iodine/ml or 300 mg iodine/ml (0,5-2 ml)
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- Examination of the gastrointestinal tract:
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- Orally. Adults
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240 mg iodine/ml or 350 mg iodine/ml (the volume is selected individually)
- Orally. Children. Esophagus
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300 mg iodine/ml or 350 mg iodine/ml (2-4 ml/kg body weight). Max. dose 50 ml
- Orally. Children. Stomach
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Dilute with water to a concentration of about 140 mg iodine/ml (4-5 ml/kg body weight)
- Orally. Premature babies
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350 mg iodine/ml (2-4 ml/kg body weight)
- Rectal administration. Children
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Dilute with water to a concentration of about 100-150 mg iodine/ml (5-10 ml/kg body weight)
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- CT scan:
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-
- Orally. Adults
-
Dilute with water to a concentration of about 6 mg iodine/ml (800-2 000 ml of diluted solution for one period of time)
- Orally. Children
-
Dilute with water to a concentration of about 6 mg iodine/ml (15-20 ml/kg body weight of the diluted solution)
- Rectal administration. Children
-
Dilute with water to a concentration of about 6 mg iodine/ml (volume - individually)
