Adults and adolescents aged 12-18
- treatment of infections of the skin and mucous membranes caused by HSV, including newly diagnosed and recurrent genital herpes (Herpes genitalis), as well as labial herpes (Herpes labialis);
- prevention (suppression) of recurrent infections of the skin and mucous membranes caused by HSV, including genital herpes, including in adults with immunodeficiency;
- prevention of infections caused by cytomegalovirus (CMV), and diseases after transplantation of parenchymal organs.
Adults
- Treatment of herpes zoster (Herpes zoster) and herpes zoster ophthalmic.
The drug is taken regardless of food intake, the tablets should be taken with water
Treatment of HSV infections of the skin and mucous membranes, including newly diagnosed and recurrent genital herpes (Herpes genitalis) and herpes labialis (Herpes labialis)
Immunocompetent adults and adolescents aged 12 to 18 years
500 mg 2 times a day
Prevention (suppression) of recurrent infections of the skin and mucous membranes caused by HSV, including genital herpes, including in adults with immunodeficiency
Immunocompetent adults and adolescents aged 12 to 18 years
500 mg once a day
Adults with immunodeficiency
500 mg 2 times a day
Prevention of infections caused by CMV and diseases after transplantation of parenchymal organs
Adults and adolescents aged 12 to 18
2000 mg 4 times a day, given as early as possible after transplantation
Treatment of herpes zoster (Herpes zoster) and herpes zoster ophthalmic
Adults
1000 mg 3 times a day for 7 days
Children
The effectiveness of drug treatment in children has not been studied
Elderly patients
It is necessary to take into account the possible impairment of renal function in elderly patients, the dose of the drug should be adjusted accordingly. Adequate water and electrolyte balance must be maintained
Patients with impaired renal function
It is recommended to reduce the dose of the drug in patients with expressed
Additional information for indication: Treatment of skin and mucous membrane infections caused by HSV, including newly diagnosed and recurrent genital herpes (Herpes genitalis) and labial herpes (Herpes labialis)
There is no experience of using the drug in children with creatinine clearance values less than 50 ml / min / 1.73 m2
Additional information for indications: prevention of CMV infections and diseases after parenchymal organ transplantation
It is necessary to frequently determine creatinine clearance, especially during a period when renal function is changing rapidly, for example, immediately after transplantation or graft engraftment, while the dose of the drug is adjusted in accordance with the creatinine clearance parameters
Additional information for indication: Treatment of herpes zoster (Herpes zoster) and ophthalmic herpes zoster
The drug should be used after hemodialysis in patients undergoing periodic hemodialysis
Patients with impaired liver function
Based on a study using a single dose of 1000 mg valacyclovir in adult patients with mild to moderate hepatic cirrhosis (with preserved synthetic liver function), dose adjustment of the drug is not required. Pharmacokinetic data in adult patients with severe liver dysfunction (decompensated cirrhosis), with impaired liver synthetic function and the presence of portocaval anastomoses also do not indicate the need for dose adjustment, however, clinical experience with these pathologies is limited
Contraindications
There are contraindications, consult with a specialist before use
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